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73,85 Target Modification The influence of GSH on redox homeostasis can impact mutation rates and post-translational modifications of antibiotic targets

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It seems likely that Samuel has an unstable variant of glucose 6-phosphate dehydrogenase, which is denatured more rapidly than normal at 45C, and therefore presumably is also less stable than normal in vivo, so that his older red blood cells will have very much less enzyme than normal