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However, tesofensine faces significant challenges - cardiovascular side effects (increased heart rate and blood pressure) raised safety concerns, FDA has not approved it despite promising efficacy data, development stalled after Phase 3 trials, currently available only through research chemical suppliers with questionable legality, and the stimulant-like mechanism creates dependency and tolerance risks not seen with GLP-1 agonists

The multiple sclerosis model using cuprizone-induced demyelination demonstrated reduced motor disability and preserved myelin with peptide treatment

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It is also said to have antioxidant and anti-inflammatory properties.it, when used in skincare formulations, is typically added to serums, creams, or lotions to enhance the skin's elasticity, reduce the appearance of scars, and promote overall skin health