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The multiple linear regression models included covariates such as sex, age, physical activity, alcohol intake, body mass index, estimated glomerular filtration rate, diabetes, hypertension, and dyslipidemia, and included the interaction between the smoking factors and sex

In particular, the metabolism of dietary substrates such as choline and l-carnitine to trimethylamine (TMA) and subsequently to trimethylamine oxide (TMAO) by a hepatic enzyme flavin-containing monooxygenase 3 (FMO3) is of interest due to the strong associations of high circulating TMAO concentrations with the risk of numerous metabolic diseases and the risk of death from heart failure [4,5,6]

[DOI] [PubMed] [Google Scholar] 108.Dillard CJ, Litov RE, Savin WM, Dumelin EE, Tappel AL

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