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Methods Materials Required for Drug Preparation Soybean lecithin, DSPE-PEG2000 and DSPE-PEG2000-Maleimide was purchased from Xian Ruixi Biological Technology Co., Ltd, oridonin from MCE, and DCM from Sigma-Aldrich

The ELP domain is not shown, but it is assumed that the ELP is aggregated into a solid phase by binding to one another

The results demonstrated a substantial decrease in BACE1 levels without any kind of neurotoxicity, thus presenting an alternative for optimal siRNA delivery in gene therapy for AD

Antibodies are eluted from Protein A, Protein G, and Protein L agarose beads using an acidic elution buffer such as tris-glycine or citric acid in the pH ~ 2.5 4.0 range