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Mechanisms underlying drug-induced ototoxicity The possible mechanisms by which ototoxic agents can influence auditory function are nerve demyelination, apoptosis via caspase cascade, glutamate toxicity, ROS overload, DNA/RNA damage, inhibition of mitochondrial protein synthesis, inner ear hypo-perfusion and ion disturbance on the background of gene mutations, and increased permeability of triggered drugs (Fig

How to Rotate Injection Sites Properly Site rotation is essential for preventing lipohypertrophythickened, fibrous tissue that develops when you inject repeatedly in the same spot

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