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Prodrugs are conjugated to RNA nanoparticles via efficient click chemistry, creating an ester linker that is cleaved by esterases in tumor tissues or cells, allowing the prodrugs to return back to their original structures and chemistry upon delivery and release, minimizing toxicity

BMC Pharmacol Toxicol 17(1):44 Koppad AK et al (2017) Evaluation of serum vitamin B12 levels in type 2 diabetes patients on metformin therapy attending a tertiary care hospital