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In the MAD cohorts, all subjects but one individual in cohort 8 (210 mg) were positive for ADA at one or more timepoints ( Figure 2B )

1 Introduction Alzheimers disease (AD) is the most common neurodegenerative disease worldwide, affecting approximately 55 million people ( The pathologic hallmarks of AD are beta amyloid (A) plaques and tau neurofibrillary tangles which contribute to neurologic damage characteristic of AD

Definition ChEBI: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine