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A prospective cohort study with Helicobacter pylori-infected patients shows that 33% of the patients treated with omeprazole for 5 years developed an atrophic gastritis with a significant decline of serum vitamin B12 levels (T0: 340 T1: 280pmol/L, p 1year) with omeprazole

In the general population, the prevalence of chondromalacia can be as high as 36.2%, with rates reaching up to 50% in middle-aged individuals between 30 and 40 years of age (8)