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251 Notably, PHDs use iron, ascorbate, oxygen, and 2-oxoglutarate to hydroxylate and inhibit HIF1, while ROS disrupt these interactions, causing HIF1 accumulation

Acknowledgements We are grateful to Tibor Pli and Andrs Dr from the Institute of Biophysics, HUN-REN Biological Research Centre for providing access to the spectrofluorometer Fluorolog 3 (Horiba Jobin Yvon) and to the Malvern Zetasizer Nano ZS device (Malvern Instruments)

10.2174/092986711794927694 lvarez-Barrios A, lvarez L, Garca M, Artime E, Pereiro R, Gonzlez-Iglesias H: Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins