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Poster Session I - RECOVERY, REHABILITATION AND OUTCOME 03.00 - RECOVERY, REHABILITATION AND OUTCOME - 03.01 - REHABILITATION P259 - ESOC25-1483 A SYSTEMATIC REVIEW OF THE PHARMACOLOGICAL INTERVENTIONS FOR POST STROKE COGNITIVE IMPAIRMENT Sara Fakhraie 1 , Aynaz Hatami 2 , Armin Jabraili 3 , Nadia Doostar 4 , Hanie Karimi 5 , Hesam Shahabifard 6 , Ramin Ahangar-Sirous 7 , Mojtaba Azari 8 , Morteza Azari 8,9 , Reza Mosaddeghi 10 , Saeed Sadigh-Eteghad 1 , Amirreza Naseri 2 1 Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, 2 Faculty of medicine, Tabriz University of medical sciences, Tabriz, Iran, 3 Faculty of Medicine, Islamic Azad University of Ardabil, Ardabil, Iran, Ardabil, Iran, 4 Faculty of Medicine, Ardabil University of medical sciences, Ardabil, Iran, Ardabil, Iran, 5 School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Iran, 6 Neurosciences Research Center,Tabriz University of medical sciences,Tabriz,ran Orcid : 0000000206758483, Tabriz, Iran, 7 Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran Tabriz, Iran, 8 1

It is typically given by intramuscular injection

They likely reflect the difference between pathological IGF-1 excess (which does appear to increase cancer risk and accelerate ageing in some models) and normalisation of IGF-1 in individuals whose levels have declined below an optimal physiological range due to somatopause

These findings align with the cuprizone-induced demyelination shown earlier (25)