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Acknowledgements This work was supported by the CAMS Innovation Fund for Medical Sciences (2019- I2M-5-035, to L.L.), the National High-Level Hospital Clinical Research Funding (2022-PUMCH-B-128, to H.Z.), and the Fundamental Research Funds for the Central Universities (3332024129, to Z.Y.X.)

Symptomatic and Disease-Modifying Therapy Pipeline for Alzheimers Disease: Towards a Personalized Polypharmacology Patient-Centered Approach

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Disrupting MYSM1 (Myb like, SWIRM and MPN domains 1), a histone deubiquitinase, can compromise human HSC function, mimicking the bone marrow failure seen in patients, by triggering lipid peroxidation and ferroptosis [203]