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PMID: 38987173 bioRxiv Intestinal fructose metabolism drives unsaturated fat absorption and synergizes with GLP-1 receptor agonism to promote weight loss

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Longevity pathway activation NAD+ plays a crucial role in activating sirtuins, a family of proteins involved in cellular repair, stress response, and aging

A brief overlap-free transition period, stopping the injectable and allowing washout before starting orforglipron, prevents excessive GLP-1 receptor stimulation