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Further, high glucose sensitizes HepG2 cells towards apoptosis [18] and induces the expression of CYP2E1 in VL-17A cells [21]

Weight fluctuates daily due to water retention, food volume, and hormonal cycles, so weekly averages provide better data than daily numbers

The resultant increased levels of the chemokines and other proinflammatory reactions, are thought to contribute to tubule-interstitial disease (Qian et al., 2010), decreased renal perfusion and intra-tubular casts formed by the interaction of heme proteins with Tamm-Horsfall protein (Tracz et al., 2007)

All of these are normal variations from the manufacturing process