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While both sCSD and sB contain the 9092 amino acid sequence reported to regulate eNOS activity, sB may be more effective than sCSD and a better candidate for drug development because of its smaller size resulting in easier synthesis, improved tissue penetration, and a decreased potential for causing side effects including an immune response

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Thioredoxins are low-molecular-weight proteins (1012 kDa) with a redox-active disulfide bond capable of transferring reducing equivalents to other protein targets via a dithiol exchange reaction (Fig

Excessive ROS, particularly superoxide and hydrogen peroxide, is present in the kidneys of animal models of hypertension and may contribute to the development of hypertension through several mechanisms, such as decreasing NO bioavailability 46,65