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Under the action of GM, flavonoid glycosides are first hydrolyzed to aglycones in the intestinal tract, then reduced, with the hydrogenation of the C-ring, after which OC2 bonds in the C-ring are cleaved to form phenolic ketones and phenolic acids (Figure 1)

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The NQO1-elicited enhancement of whole-body glucose metabolism appears to be mediated, at least in the Keap1 -KO mouse model, by increases in the constitutive NRF2 transcriptional activity, a pleiotropic regulator of the oxidative stress response

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies