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When ROS increases, the synthesis of mitochondrial fusion-related proteins will be inhibited, thus promoting mitochondrial fission, which in turn may lead to more ROS production and severe mitochondrial dysfunction

[DOI] [PubMed] [Google Scholar] 6.Vigliani E.C., Baldi G

Acta Otorhinolaryngol Ital 40(3):224229

Fredriksson L, Wink S, Herpers B et al (2014) Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity