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Dilated cardiomyopathy in transgenic mice expressing HIV Tat

The imbalance in calcium and iron depletes and alters the glutathione (GSH) enzyme responsible for the antioxidant defense against xenobiotics (e.g., external chemicals, drugs, pesticides, carcinogens) for detoxification by making these compounds more soluble

The p38 MAPK/STAT6 pathway is involved in ferroptosis-induced VEGFA and IL8 induction We further investigated the mechanism of ferroptosis-induced VEGFA and IL8 upregulation in ESCs