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KalecNPeraniNMamiIBeusMHallCRSmithTAet al

The compound acts as a biological switch rather than a sustained agonist

Interestingly, Day 45 organoids exhibited a shift toward a mesenchymal cell profile, with increased markers of hepatic stellate cells, suggesting utility for disease modeling applications

Incomplete responses to systemic therapies might reflect the coexistence of several distinct populations of resistant cancer cells, including dormant tumour cells, cancer stem cells, clones harbouring primary resistance and DTPs