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Indeed, early studies have found that hydrochlorothiazide has the potential to influence various facets of glucose homeostasis, spanning from insulin secretion in the islets to the production of glucose in the liver and kidneys under diverse physiopathological conditions in humans and animal models

Erythrocytes dont have the intrinsic apoptotic machinery upstream of caspase-3, including cytochrome c or apoptotic peptidase-activating factor 1 (APAF-1) [22, 23]