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Finally, the treatment of whole blood cultures of individuals in the CTRL group with B12 did not change the expression levels of any gene assessed

Possible explanations for this phenomenon are as follows: (1) generally, infectious diseases are more common and/or severe in diabetic patients since the hyperglycemic environment can lead to immune dysfunction, vascular disease, neuropathy and decrease in antibacterial activity of the digestive tract [186]

Ultimately, this induces an abnormal increase in reactive oxygen species (ROS) within intestinal epithelial cells, leading to oxidative stress 30

While short-term LC supplementation has demonstrated positive effects, including increased endurance, improved hepatic fat metabolism, and myocardial stability, evidence indicates that the prolonged supplementation may pose risks, particularly for individuals with pre-existing cardiovascular or renal conditions