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Extended high-frequency audiometry (920 kHz) may detect early basal cochlear damage before standard frequencies are affected, providing a critical window for intervention ( Historically proposed schedules include baseline assessment, weekly monitoring during treatment, and follow-up at 1, 3, and 6 months post-treatment to detect delayed-onset or progressive losses ( Vestibular function assessment is frequently overlooked, despite well-recognized vestibulotoxicity risk posed by aminoglycosides as a class

It reduces declines in mental abilities resulting from Alzheimer's disease and other neurodegenerative diseases

Metabolic activation of specific natural products from herbal and dietary supplements is mediated by hepatic cytochrome P450 or intestinal bacteria, and generates chemical reactive/toxic metabolites that bind to cellular reduced glutathione or macromolecules, and form reactive metabolites-glutathione/protein/DNA adducts, and these protein/DNA adducts can result in toxicities

Moreover, compared to healthy control specimens, plasma and tissue riboflavin levels were decreased in patients with cervical squamous epithelial cancer and cervical intraepithelial dysplasia, respectively