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It can come from a herniated disc or bone overgrowth in the spine

Hence, by targeting the enzymatic activity of SARM1, inhibitors may effectively prevent the depletion of NAD + , thereby maintaining cellular energy homeostasis and enhancing neuronal resilience, potentially expanding the treatment landscape for various neurological conditions

Even compounds with known intracellular targets, such as the estrogen receptor modulator raloxifene, may protect hair cells by inhibiting aminoglycoside entry, rather than acting via modulation of estrogen signaling (Vlasits et al., 2012)

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