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Human studies using Lactobacillus as a probiotic have often demonstrated decreased body weight and/or body fat in a strain-dependent manner (for a review of human studies, see Crovesy et al., 2017 58 ), suggesting that the NNMTi-and-LD-mediated changes to Lactobacillus relative abundance may be critical to NNMTi-mediated weight loss

131 , e136055 (2021)

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For the analysis, we selected genes that encode key MeOH-metabolizing enzymes ( ADH1, ALDH2, CAT, CYP2E1 , and ADH5 ) and NRF2, which is encoded by the NFE2L2 gene and is a well-known sensor of oxidative stress (Prasad, 2016)