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A larger study (SEMA-NASH) enrolling 320 individuals with obesity, biopsy-proven NASH and different degrees of fibrosis, with or without diabetes, demonstrated that OD subcutaneous semaglutide 0.4 mg significantly resolved MASH without worsening fibrosis in 59% of patients 93

Moreover, the SURMOUNTMMO (tirzepatide, NCT05556512) will assess the impact of the dual GLP-1/GIP RA in cardiovascular outcomes and all-cause mortality for people with obesity (without diabetes) when the REDEFINE-3 study will assess the impact of cagrisema in people with obesity (with and without T2DM) and established cardiovascular disease

Shang J, Zheng Y, Yang Y, Liu C, Geng Q, Tai W, Du L, Zhou Y, Zhang W, Li F (2018) Cryo-electron microscopy structure of Porcine deltacoronavirus spike protein in the prefusion state

The geometric mean ratio for the primary end point, midazolam AUC inf in the presence to absence of kratom, lay outside the predefined no-effect range (0.751.33)