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Based on several human studies, food folate (a mixture of natural reduced pteroylmono- and polyglutamates) has a lower bioavailability than synthetic monoglutamate folic acid added to foods for supplementation and food fortification purposes

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Several studies showed evident association between type II diabetes and cancer, in particular in liver and pancreas, organs persistently exposed to high levels of endogenous insulin 117,118,119

For example, cisplatin (CDDP) readily forms complex with GSH after hydrolysis in the cytoplasm, making it unable to enter cell nucleus and bind to the target DNA [18, 19]