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So we look at proxies in animals where you can do virtually anything you want in a totally controlled setting but then you run the risk of two things

Preventing denervation muscle atrophy: Allowing the muscle cells to perform their function while the reconstructive processes take place

Bioavailability Moderate absorbs through the nasal lining and can partly bypass the gut

For instance, medical digital twinscomputational models that replicates human biology relevant to a compound or interventionare gaining traction in medical research 55