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Conversely, downsizing to 70 years), NAD + depletion, driven by reduced NAMPT expression, impairs sirtuin-1-mediated mitochondrial biogenesis, diminishing energy reserves in peri-infarct regions by 60% compared to younger individuals [243, 244]

Processing, visualization, and analysis of mass spectrometry data were carried out using MZmine Version 2.53

Recruitment of transcription factors Histone acetylation plays a crucial role in facilitating the recruitment of transcription factors and other regulatory proteins