glutathione for liver fibrosis Dysregulation of synthesis in disease Hepatocyte glutathione S-transferase mu 2

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doi:10.1007/s00345-023-04512-x

In particular, the contribution of HDAC4 to the sumoylation for MEF2 finally leads to transcription inhibition [80] while HDAC4-mediated sumoylation of ZXDC activates the transcription activity [81]

However, when activated in response to injury, infection, or disease, microglia can change into a pro-inflammatory state, producing a wide range of inflammatory molecules such as cytokines (e.g., TNF-, IL-1), ROS, and proteases, all of which contribute to tissue damage and neurodegeneration [140]