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Name: does l carnitine make you have diarrhea l-carnitine: Nutrition, pathology, and health
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Mandel S, Amit T, Reznichenko L, Weinreb O, Youdim MBH (2006) Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders

Although applying it to the skin could help, the results might not show up immediately as they would with other approaches

10.1074/jbc.c400260200 68 KillingerB

Finally, hydrogels with good biocompatibility, low immunogenicity, and modifiable physical and chemical properties can be ideal carriers to improve efficacy and reduce the toxicity of natural products (Yegappan et al., 2018