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Xiang Y, Wang H, Ding H, Xu T, Liu X, Huang Z, Wu H, Ge H

Interestingly, GPC-6 AA genotype also played a strong protective role against anastomotic strictures but only for recipients (p 20000 IU/ml & elevated ALT)

PB-TURSO (sodium phenylbutyrate + taurursodiol) Slowed AlSFRS-R decline in the phase 2/3 CENTAUR RCT (basis for 2022 FDA approval) but failed in the phase 3 PHOENIX trial and was voluntarily withdrawn from U.S./Canada in 2024