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Biomarker Effects Were Present Despite clinical failure, semaglutide showed biological activity: CSF biomarkers including pTau181, pTau217, and others demonstrated nominally significant reductions of approximately 10% in treated patients

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Another option is to use recombinant Cas9 proteins, which produce mutations at on-target sites as soon as they are introduced into cells and are promptly eliminated by cellular protease machinery, reducing off-target effects [315]

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