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Under pathological conditions, disruption of this apical microenvironment is likely to contribute to abnormal secretion and intracellular zymogen activation, but the specific contribution of mitochondria to these events appears to be predominantly indirect

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Himly M, Grotz B, Sageder M, Geppert M, Duschl A

In this context, a protective effect might be observed (in compar- ison with untreated animals), but the initial ROS genera- tion should initiate necrosis of the OHCs and consecutive- ly hearing threshold shifts