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Glucose uptake in normal cells is strictly regulated but, malignant cells have been reprogrammed to fuel unconstrained proliferation (77) and many malignant cell types have been reported to take up glucose at unusually elevated rates

Furthermore, LXR activation raises the generation of lactate and acetyl-CoA, upregulates the expression of SREBP1 and stimulates the mevalonate pathway and IL-1 signaling in human monocytes, thereby contributing to a pro-inflammatory trained immunity phenotype (Sohrabi et al., 2020)

Mechanisms linking endoplasmic reticulum (Er) stress and micrornas to adipose tissue dysfunction in obesity