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It was originally studied in the context of gastrointestinal healing, where the parent protein appears to play a role in protecting the gut lining

EGCGs multifaceted biological activities, documented in high-impact journals like Nature, Cell, and Molecular Nutrition & Food Research, include mitigating oxidative stress, modulating inflammatory responses, regulating cellular proliferation, and supporting metabolic homeostasis [15]

The phase 2 trial ran for 48 weeks total, and the weight loss curve had not fully plateaued by that point, suggesting continued benefits beyond the trial period

In terms of one-carbon metabolism support, intermediate metabolites of the SSP participate in one-carbon unit transfer primarily through serine hydroxymethyltransferase 2 (SHMT2), supplying raw materials for purine and pyrimidine biosynthesis as well as DNA methylation