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In the STEP 1 extension, participants who came off semaglutide regained roughly two thirds of the weight they had lost within a year, and the improvements in blood pressure, lipids and glycemic markers moved back toward baseline (PMID 35441470)

A 2015 meta-analysis of 15 trials (1,106 patients) confirmed that IV methylcobalamin (5001,500 mcg/day) combined with alpha-lipoic acid improved nerve conduction velocity by 2030% more than monotherapy, reducing tingling and burning sensations

Factors such as your metabolism, genetic predisposition, lifestyle habits (like diet, exercise, and sleep), and individual response to B12 can all influence the timeline for experiencing improvements