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After absorption, B12 is bound to transport proteins, 7580% to haptocorrin, which transports B12 in the blood, and 2025% to transcobalamin, which delivers B12 to the tissues, also referred to as active B12 or holo-transcobalamin

2 With the development of birth control pills in the 1950s, the FDA approved use of the pill with its synthetic hormone-mimicking chemicals to suppress heavy menstrual bleeding