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However, for nebulized antibiotics the interpretation of the antibiogram should take into consideration that, through this form of delivery, antibiotic achieves much higher concentrations in the bronchial mucosa overcoming the mechanisms of resistance.77 The persistence of bacteria despite aggressive treatment is thought to be due to several factors such as poor penetration of antibiotics into purulent airway secretions, native or acquired antibiotic resistance and production of biofilms by the bacteria that may render antibiotics ineffective or interfere with host defences

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As soon as the catalytic mechanism of GPx was discovered, the design and development of synthetic compounds mimicking GPx-like activity became an active research area [71,72,73]

we observed a 11.7-fold change for venetoclax, a 18.4-fold change for AZD-5991, and an 5.5-fold change for ibrutinib