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112 DAN encompasses multiple subtypes, including cardiovascular autonomic neuropathy (CAN), gastrointestinal autonomic neuropathy, genitourinary autonomic neuropathy, sudomotor dysfunction, hypoglycemia unawareness, and pupillary dysfunction, each affecting different organ systems and presenting a spectrum of clinical manifestations

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however, this finding was challenged by the finding that these ACSL4 inhibitors have inherent antioxidant activity [113]