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For instance, reduced Mn levels have been reported in patients with cervical cancer, and a low Mn status has been correlated with both tumor growth and metastasis in patients with epithelial ovarian cancer 274

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Endogenous sources of ROS Endogenous sources of ROS include various cellular organelles and enzymatic reactions within the body: Mitochondria Mitochondrial ROS generation primarily occurs at complexes I and III of the ETC due to electron leaks that fail to reach complex IV and instead univalently react with oxygen to form O 2