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p53 can transcriptionally inhibit the activity of PS1

acidocaldarius GKs, belonging to the FGGY family within the sugar kinase/HSP70/actin superfamily, with significant similarity to both archaeal and bacterial enzymes, as well as eukaryotic counterparts

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( FIGURE 9 In intervertebral disc degeneration (IDD), the imbalance between reactive oxygen species (ROS) generated by oxidative stress and intracellular antioxidant defense mechanisms leads to structural and functional abnormalities, exacerbating disc degeneration (Wang et al., 2023)