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It follows that, if a refundable drug becomes multiple source drug mid-way through a quarter, it would be a multiple source drug for the entire quarter and would not meet the definition of refundable drug for the quarter, provided that both the original product (likely the reference listed drug) and one or more therapeutically equivalent products are marketed and sold in the same quarter

For example, introducing exogenous mRNA into parent cells can be packaged into EVs and then delivered to target cells to induce specific gene expression (Zomer et al., 2015