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IFV, SARS-CoV-2, RSV and AdV had the most drugs for treating heat syndrome, followed by drugs for treating the symptomatic syndromes of phlegm, dampness, wind and toxin, and the pattern of their use was consistent with the trend of TCM evidence for viral pneumonia, suggesting that TCM practitioners can adopt the same or different treatments according to similarities and differences in the constituent elements of diseases

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In the centrilobular hepatocytes, there was substantial proliferation of rough endoplasmic reticulum, as shown by electron microscopy with slightly less than half of the periportal hepatocytes showing rough endoplasmic reticulum proliferation

Interestingly, elevated pyroglutamate levels have been associated with toxic effects 37 , as its accumulation may disrupt redox homeostasis and interfere with glutamate metabolism