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However, since hormonal fluctuations are primarily responsible for melasma, reversing this behaviour can be challenging

Bile acids play an important role in regulating intestinal barrier function, lipid metabolism, and immune response, and their metabolic disorders may lead to impaired intestinal barrier function, promote the production of inflammatory factors, and further affect the pathological process of PD

Li S, Guerin-Deremaux L, Pochat M, Wils D, Reifer C, Miller LE

The defect involves pH-dependent TRPML1-mediated efflux of calcium that activates c-Jun amino-terminal kinase ( JNK)-mediated phosphorylation of dynein intermediate chains, and thereby impedes retrograde motility 19