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4 Histone acetylation is decreased by IDH1 inhibition or mildronate in vivo and cannot be rescued by propionylcarnitine or butyrylcarnitine

Excessive NO, particularly when reacting with superoxide anion (O 2 ) to generate peroxynitrite (ONOO ), exerts cytotoxic effects through mechanisms such as DNA damage, lipid peroxidation, and protein nitration

AHK-Cu has far fewer published studies, and much of the evidence supporting its efficacy comes from industry-sponsored reports and patent filings rather than peer-reviewed academic research

Libraries were constructed from the samples and sequenced to obtain second-generation data