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Selenium: A cofactor for glutathione peroxidases, supporting antioxidant defenses

Alzahrani and colleagues reported in 2025 that intravenous glutathione is associated with serious safety concerns like anaphylaxis and hepatotoxicity. Regulatory bodies have issued clear warnings: Philippine FDA (2025): The FDA has not approved any injectable products for skin lightening UK Trading Standards (June 2025): Public warning about dangerous glutathione IV drips No professional dermatology organization endorses IV glutathione for skin lightening purposes

E2 supplementation restores membrane lipid integrity by enhancing expression of antioxidant enzymes and reducing oxidative phospholipid generation, thereby limiting inflammatory phospholipid signalling and complement activation

Next, to examine whether revSCs can give rise to CBCs oppositely, we established collagen organoids from Lgr5 DTR-EGFP mice, sorted Ly6a+/Lgr5 revSCs population, and replated them into Matrigel (Fig