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Extended escalation for sensitive individuals If standard 4-week intervals produce intolerable side effects, extending each phase to 6 or 8 weeks is a reasonable modification

These include: Paraesthesia (pins and needles) in hands and feet Difficulty walking or balance problems Memory impairment and cognitive changes Mood disturbances, including depression and irritability Visual disturbances (rare, such as optic neuropathy) Gastrointestinal symptoms such as diarrhoea, constipation, or loss of appetite may also occur, particularly when deficiency results from malabsorption

More alarming, vitamin B12 deficiency was twice as common among those taking metformin

BIO BOOST + PLUS ("COMBO SHOT")* B5 - Dexpanthenol Helps produce energy by breaking down fats and carbohydrates