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Conclusion Methylsulfonylmethane (MSM) and glycine represent integral components of human biology, each contributing uniquely to various physiological functions and health benefits

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Conversely, we have also demonstrated that exacerbated activation of the BH4 pathway is pathogenic, causing mitochondrial dysfunction, increasing the aggressiveness of the immune system, inducing pain hypersensitivity, and the progression of symptoms of chronic diseases, including chronic pain, asthma, multiple sclerosis, ulcerative colitis, rheumatoid arthritis, cognitive impairment, and others [83,84,85,86,87]

Cancer Research 42, 51475151 (1982)