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Acridone, analogous to CPT, possesses a planar ring structure that allows it to act as a DNA intercalator and inhibit topoisomerase [79]

Studies have shown that tumour-conditioned medium (TCM) collected from the supernatant of human primary glioma cells can upregulate the expression of suppressor of cytokine signalling 1 (SOCS1) in DCs and then inhibit the NF-B signalling pathway, thereby limiting the maturation of DCs