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Consider pharmacokinetics, tissue binding, and degradation when choosing the route

Consequently, Nrf2 levels increase in the cytoplasm, where Caspase-3-cleaved PKC further activates Nrf2 via Ser40 phosphorylation, enabling its nuclear translocation to activate ARE expression

Intensive research, including ours, has shed light on the underlying mechanisms, including hypoxia, cell cycle arrest, sustained oxidative stress, and mitochondrial dysfunction (8)