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doi: 10.1007/s11095-021-03045-5 47 WeiYSongSDuanNWangFWangYYangYet al

Specifically, these reactions are carried out by Phase I enzymes, which introduce hydroxyl, thiol, and amine functional groups to the xenobiotic scaffold, and Phase II enzymes, which transfer glucuronide, sulphate, and glutathione moieties onto the Phase I functional groups or the xenobiotic scaffold 7,9